Relationship of serum adipocytokine levels with glucolipid metabolism and micro-inflammatory state in obese children

摘要

Objective:To analyze the relationship of serum adipocytokine levels with glucolipid metabolism and micro-inflammatory state in obese children.Methods: A total of 299 obese children and 264 normal children were included in the study, fasting peripheral venous blood was extracted to determine serum levels of adipocytokines, glucolipid metabolism and micro-inflammation-related indexes, and the correlation between the levels of adipocytokines and the levels of glucolipid metabolism and micro-inflammation-related indexes was further analyzed. Results:Serum leptin and Vaspin levels of observation group were higher than those of control group, and APN level was lower than that of control group (P<0.05); serum FINS, C-P, Cor, TG and LDL-C levels were higher than those of control group, and HDL-C level was lower than that of control group (P<0.05); serum hs-CRP, IL-8, IL-6 and TNF-αlevels were higher than those of control group (P<0.05); serum Leptin, APN and Vaspin levels were directly correlated with the levels of above glucolipid metabolism and micro-micro-inflammatory state indexes.Conclusions:There are high expression levels of inflammatory factors and glucolipid metabolism disorder in obese children, and excessively expressed adipocytokines may be the important factors of persist and worsened obesity.