Influence of adjuvant reduced glutathione therapy on oxidative stress and inflammation in patients with maintenance hemodialysis

摘要

Objective: To study the influence of adjuvant reduced glutathione therapy on oxidativestress and inflammation in patients with maintenance hemodialysis. Methods: A total of 112patients with end-stage renal disease who received maintenance hemodialysis in our hospitalbetween July 2012 and February 2016 were chosen and divided into control group (n=56) andobservation group (n=56) according to random number table. The control group were treatedwith routine maintenance hemodialysis, and the observation group were treated with MHDplus reduced glutathione therapy. Serum contents of oxidative stress indexes and inflammationindexes were compared between two groups of patients before and after treatment. Results:Before the intervention, differences in serum levels of oxidation indexes/anti-oxidationindexes as well as pro-inflammatory indexes/anti-inflammatory indexes were not statisticallysignificant between two groups of patients. After intervention, serum oxidation indexes MDAand AOPP levels of observation group were lower than those of control group, anti-oxidationindexes GSH-Px, T-AOC and SOD levels were higher than those of control group, proinflammatoryindexes IL-1β, IL-6 and IL-2 levels were lower than those of control group,and anti-inflammatory indexes IL-8 and IL-13 levels were higher than those of control group.Conclusion: Adjuvant reduced glutathione therapy helps to maintain the oxidative/antioxidantas well as pro-inflammatory/anti-inflammatory balance in patients with maintenancehemodialysis, and relatively reduce the oxidative stress and inflammation.