Correlation of serum ICAM-1 and VEGF levels with microvascular injury in patients with senile diabetic retinopathy

摘要

Objective: To study the correlation between serum vascular endothelial growth factor (VEGF) and intercellular adhesion molecule (ICAM) -1 level and microvascular injury in elderly diabetic retinopathy, and provide reference for clinical diagnosis and treatment. Methods: A total of 268 diabetic patients in our hospital in October 2015 -2017 year in October, on the basis of fundus fluorescein angiography and fundus examination were divided into proliferative diabetic retinopathy group (PDR), background diabetic retinopathy group (BDR) and diabetic retinopathy group (NDR), and 100 healthy at the same time to participate in the examination of our hospital as the control group. The changes of ICAM-1, VEGF and nitric oxide (NO), von Willebrand factor (vWF), endothelin-1 (ET-1) and thrombomodulin (TM) and other vascular endothelial function indexes in four groups were compared. Results: NDR group, BDR group, PDR group, ICAM-1, VEGF, NO and vWF (except NDR group), four ET-1 TM and vascular endothelial function indexes were significantly higher than the control group, while the difference between NDR vWF group was not statistical significant; differences in ICAM-1, VEGF and NO, vWF, ET-1 and TM four vascular endothelial function index among NDR group, BDR group and PDR group were statistically significant. Compared with the two groups, four vascular endothelial function indexes of ICAM-1, VEGF and NO, vWF, ET-1 and TM in retinopathy group were significantly higher than those in control group. Conclusions: There is correlation between VEGF, ICAM-1 level and microvascular injury in senile diabetic retinopathy patients. The late progression of the disease is, the higher VEGF, ICAM-1, NO, vWF, ET-1 and TM of vascular endothelial damage indexes are.It can reflect the microcirculation the extent of injury and blood rheology, and change of coagulation mechanism. It is worthy for clinical reference.