Effect of multidimensional rehabilitation on the neurotrophy state and inflammatory response - apoptosis mechanism in patients with schizophrenia

摘要

Objective: To study the effect of multidimensional rehabilitation on the neurotrophy state andinflammatory response-apoptosis mechanism in patients with schizophrenia. Methods: Patientswith schizophrenia who were treated in West China Hospital, Sichuan University betweenFebruary 2015 and April 2016 were selected and randomly divided into two groups, themultidimensional group received multidimensional rehabilitation therapy, and the conventionalgroup received conventional rehabilitation therapy. The levels of neurotrophy indexes,inflammatory response indexes and apoptosis molecules in serum as well as the expression ofapoptosis molecules in peripheral blood were measured before treatment and 6 months aftertreatment. Results: 6 months after rehabilitation, serum NGF, BDNF, IGF-1 and IGF-2 levelsof both groups of patients were higher than those before rehabilitation while serum sTNFR1,sTNFR2, TNF-α, IL-1β, FasL, Fas and Caspase-3 levels as well as peripheral bloodFasL, Fas and Caspase-3 expression were lower than those before rehabilitation, and serumNGF, BDNF, IGF-1 and IGF-2 levels of multidimensional group were higher than those ofconventional group while serum sTNFR1, sTNFR2, TNF-α, IL-1β, FasL, Fas and Caspase-3levels as well as peripheral blood FasL, Fas and Caspase-3 expression were lower than thoseof conventional group. Conclusion: Multidimensional rehabilitation for schizophrenia canimprove the neurotrophy state, and inhibit the inflammatory response and apoptosis of nervecells.