Effects of glucocorticoid combined with antibiotics on serum infection indexes, acute phase proteins and stress hormones in patients with severe pneumonia

摘要

Objective: To study the effects of glucocorticoid combined with antibiotics on serum infectionindexes, acute phase proteins and stress hormones in patients with severe pneumonia.Methods: a total of 80 patients with severe pneumonia who were hospitalized between August2014 and January 2017 were retrospectively analyzed and divided into the routine treatmentgroup (n=46) who received conventional antibiotic therapy and the combined treatment group(n=34) who received glucocorticoid combined with antibiotic therapy, and the differences ininfection indexes, acute proteins and stress hormones were compared between the two groupsof patients before and after treatment. Results: The differences in serum levels of infectionindexes, acute phase proteins and stress hormones were not statistically significant betweenthe two groups before treatment. After 1 week of treatment, serum infection indexes CRP andPCT levels of observation group were lower than those of control group; serum acute phaseproteins α1-AT, α1-AG and CER levels were lower than those of control group; serum stresshormones Cor, AngⅠ and AngⅡ levels were lower than those of control group. Conclusion:Glucocorticoid combined with antibiotics can effectively inhibit systemic infection and stressand optimize the illness in patients with severe pneumonia.