Effect of dexmedetomidine combined with ulinastatin on RAAS system, coagulation indexes and oxygen free radicals after acute aortic dissection surgery

摘要

Objective: To study the effect of dexmedetomidine combined with ulinastatin on RAASsystem, coagulation indexes and oxygen free radicals after acute aortic dissection surgery.Methods: A total of 48 patients with aortic dissection who accepted endovascular graftexclusion treatment in the hospital between May 2014 and February 2017 were selected andrandomly divided into two groups, group A received dexmedetomidine, ulinastatin combinedwith general anesthesia, and group B received general anesthesia. The RAAS hormones,coagulation indexes and oxygen free radical indexes were measured 1 d before surgery,during operation and 24 h after surgery. Results: During operation and after operation, serumREN, AT-II, ALD, FIB, DD, MDA and MPO contents as well as APTT and TT levels of bothgroups of patients were significantly higher than those before operation while TAOC andTSOD contents were significantly lower than those before operation, and serum REN, ATII,ALD, FIB, DD, MDA and MPO contents as well as APTT and TT levels of group A weresignificantly lower than those of group B while TAOC and TSOD contents were significantlyhigher than those of group B. Conclusion: Dexmedetomidine combined with ulinastatinfor acute aortic dissection can inhibit RAAS system and oxygen free radical generation andimprove coagulation function.