Influence of irbesartan combined with low dose urokinase on treatment effect and serologic indexes in elderlyisolated systolic hypertension patients

摘要

Objective: To study the influence of irbesartan combined with low dose urokinase on treatmenteffect and serologic indexes in elderly isolated systolic hypertension patients. Methods: Onehundred and ten cases of elderly isolated systolic hypertension patients in our hospital duringJanuary 2013–January 2016 were randomly divided into observation group with 55 casesand control group with 55 cases. Patients in observation group received irbesartan combinedwith low dose hydrochlorothiazide treatment and those in control group received amlodipinecombined with low dose hydrochlorothiazide treatment, each lasted for 4 weeks. After 4 weekstreatment, non-invasive blood pressure and blood pressure variability indexes were measured,serum endothelial function, inflammatory factors and oxidative stress indexes were measured.Results: After 4 weeks treatment, patients systolic blood pressure (SBP), 24 h mean systolicblood pressure (24 h SBP), 24 h systolic blood pressure standard deviation (24 h SSD) weresignificantly lower in observation group than in control group (P0.05); serum endothelialfunction index EF-1 was lower in observation group than in control group, while NO andendothelial nitric oxide synthase (eNOS) were higher in observation group than in controlgroup (P0.05); serum high sensitivity C-reactive protein (hs-CRP), interleukin (IL)-1β,IL-6, IL-8, tumor necrosis factor-α (TNF-α) contents were lower in observation group than incontrol group (P0.05); serum oxidation index such as malondialdehyde (MDA) was lower inobservation group than in control group, while antioxidant indexes such as total anti-oxidativecapacity (TAC), superoxide dismutase (SOD), GSH were higher in observation group than incontrol group (P0.05). Conclusions: Irbesartan combined with low dose hydrochlorothiazidecan effectively reduce systolic hypertension and blood pressure variability in elderly isolatedsystolic hypertension patients, while optimizing the systemic inflammation and oxidative stressstatus.