Effects of prostacyclin derivatives combined with valsartan therapy on the blood biochemical indexes in patients with early hypertensive nephropathy

摘要

Objective: To explore the effects of prostacyclin derivatives combined with valsartan therapy on the blood biochemical indexes in patients with early hypertensive nephropathy. Methods: A total of 110 patients with hypertensive nephropathy who were treated in the hospital between December 2014 and March 2017 were divided into control group (n=55) and experimental group (n=55) by random number table method. Control group received valsartan therapy, and experimental group received prostacyclin derivatives combined with valsartan therapy, which lasted for 20 weeks. The differences in the contents of renal function indexes, urinary protein indexes and endothelial injury markers were compared between the two groups before and after treatment. Results: Before treatment, the differences in the contents of renal function indexes, urinary protein indexes and endothelial injury markers were not statistically significant between the two groups. After 20 weeks of treatment, renal function indexes SCr, BUN, UA and CysC levels in peripheral blood of experimental group were lower than those of control group; urinary protein indexes ALB, β2-MG and α1-MG contents were lower than those of control group; endothelial injury markers ET-1 and E-selectin contents in peripheral blood were lower than those of control group whereas NO and CGRP contents were higher than those of control group. Conclusion: Prostacyclin derivatives combined with valsartan therapy can effectively optimize the renal function, reduce the urinary protein and alleviate the vascular endothelial injury in patients with early hypertensive nephropathy and improve the overall therapeutic effect.