Effects of Yiqi Yangyin Prescription combined with radiotherapy on the tumor load and anti-tumor immune response of patients with advanced lung cancer

摘要

Objective: To investigate the effects of Yiqi Yangyin Prescription combined with radiotherapy on the tumor load and anti-tumor immune response of patients with advanced lung cancer. Methods: A total of 78 patients with advanced non-small cell lung cancer who were diagnosed and treated in our hospital between August 2015 and January 2017 were reviewed and then divided into the routine group (n=41) who received chemoradiotherapy alone and the Yiqi Yangyin Prescription group (n=37) who received chemoradiotherapy combined with Yiqi Yangyin Prescription therapy. The differences in serum levels of tumor markers, Th1/Th2 cytokines and Th17/Treg cytokines were compared between the two groups before and after treatment. Results: After treatment, serum tumor markers CA15-3, Cyfra21-1, HSP90α and CEA levels of Yiqi Yangyin Prescription group were lower than those of routine group; serum Th1 cytokines IFN-γ and IL-2 levels were higher than those of routine group while Th2 cytokines IL-4 and IL-5 levels were lower than those of routine group; serum Th17 cytokines IL-17 and IL-23 as well as Treg cytokines IL-10 and TGF-β levels were lower than those of routine group. Conclusion: Routine chemoradiotherapy combined with Yiqi Yangyin Prescription therapy can effectively reduce the tumor load and optimize the anti-tumor immune function in patients with advanced non-small cell lung cancer.