Effect of amblyopia training in regulating the amblyopic eye in children with ametropic amblyopia

摘要

Objective: To observe the influence of immunomodulator on the immunoglobulin and T cellsubsets in children with intractable epilepsy. Method: A total of 82 children with intractableepilepsy in our hospital were selected and randomly divided into 2 groups: the control group(41 cases) and the observation group (41 cases). Routine antiepileptic drugs were given to thecontrol group. Medication regimen was that more than 2 kinds of anti epileptic drugs were becombined used. But the immunomodulator wasn't used. Treatment of immune globulin wasgiven to the control group on the basis of observation group. By taking the 400 mg/kg/d asthe standard of dosage, for 5 d every course of treatment. One course of treatment was carriedout every month, 3 months in total. The changes of IgA, IgG, IgM and CD3+, CD4+, CD8+,CD4+/CD8+ were compared in 2 groups before and after treatment. Result: The comparisonof IgA, IgG, IgM in the two groups before treatment was not statistically significant. Aftertreatment, IgA, IgG in observation group were significantly higher than that before treatmentand the difference was statistically significant. However, there was no significant differenceon the IgM. There was no significant difference on the IgA, IgG, IgM in the control groupcompared with that before treatment. IgA, IgG in observation group was significant higherthan that in the control group. The comparison of IgM between 2 groups was not statisticallysignificant. The comparison of CD3+, CD4+, CD8+, CD4+/CD8+ in the two groups beforetreatment was not statistically significant. After treatment, CD3+, CD4+, CD4+/CD8+ inobservation group were significantly higher than that before treatment; CD8+ in observationgroup was significantly lower than that before treatment. The difference was statisticallysignificant. There was no significant difference on the CD3+, CD4+, CD8+, CD4+/CD8+in the control group compared with that before treatment. CD3+, CD4+, CD4+/CD8+ inobservation group was significant higher than that in the control group. CD8+ in observationgroup was significant lower than that in the control group. The difference was statisticallysignificant. Conclusion: Compared with using routine antiepileptic drugs , application ofimmune globulin as an immunomodulator combined with conventional antiepileptic drug inchildren with refractory epilepsy can effectively improve the expression of IgA, IgG, IgM andT cell subsets, which has a positive effect on the immune function of the children.