Application of inflation fluid containing ropivacaine hydrochloride in endoscopic thyroidectomy on stress response and pain mediators

摘要

Objective: To study the effect of the application of inflation fluid containing ropivacainehydrochloride in endoscopic thyroidectomy on stress response and pain mediators. Methods:128 patients receiving endoscopic thyroidectomy in our hospital between November 2015and November 2016 were selected and randomly divided into two groups (n=64), observationgroup of patients received the inflation fluid containing ropivacaine hydrochloride as theinflating medium during endoscopic thyroidectomy and control group of patients receivedsaline inflation fluid as the inflating medium during endoscopic thyroidectomy. Serum wascollected before and after operation respectively to determine the levels of stress responserelatedhormones and pain-related mediators. Results: Serum adrenocorticotropic hormone(ACTH), cortisol (Cor), norepinephrine (NE), epinephrine (E), renin (PRA), angiotensin-2(ANG-2), aldosterone (ALD), dynorphin (DYN), β-endorphin (β-EP), nitric oxide (NO) andsubstance P (SP) levels of both groups after operation were significantly higher than thosebefore operation (P0.05), and serum ACTH, Cor, NE, E, PRA, ANG-2, ALD, DYN, β-EP,NO and SP levels of observation group after operation were significantly lower than those ofcontrol group (P0.05). Conclusions: The application of inflation fluid containing ropivacainehydrochloride in endoscopic thyroidectomy can reduce the postoperative stress response andsuppress pain mediator secretion.