Correlation of serum NSE and S100β levels with inflammatory response and immune response in children with hand-foot-mouth disease complicated by encephalitis

摘要

Objective: To study the correlation of serum NSE and S100β levels with inflammatoryresponse and immune response in children with hand-foot-mouth disease (HFMD) complicatedby encephalitis. Methods: Children who were diagnosed with hand-foot-mouth disease inYulin Third Hospital between May 2015 and February 2017 were selected, children whowere combined with central nervous system were selected as severe group, and children whowere not combined with central nervous system were selected as mild group; children whoreceived physical examination during the same period were selected as the control group.Serum was collected to determine the contents of NSE, S100β and inflammatory responsemediators, and peripheral blood was collected to determine the contents of T cell subsetsand NK cells. Results: Serum NSE and S100β levels of severe group and mild group weresignificantly higher than those of control group, and serum NSE and S100β levels of severegroup were significantly higher than those of mild group; serum TNF-α, IL-6, IL-10, IL-17 and PCT levels as well as peripheral blood HLA-DR+CD4+, HLA-DR+CD8+, CD38+CD4+and CD38+CD8+ levels of severe group and mild group were significantly higher than thoseof control group while peripheral blood CD3+T cell, CD4+T cell, CD8+T cell and NK celllevels were significantly lower than those of control group; serum TNF-α, IL-6, IL-10, IL-17 and PCT levels as well as peripheral blood HLA-DR+CD4+, HLA-DR+CD8+, CD38+CD4+and CD38+CD8+ levels of severe group were significantly higher than those of mild group andpositively correlated with NSE and S100β levels while peripheral blood CD3+T cell, CD4+Tcell, CD8+T cell and NK cell levels were significantly lower than those of mild group andnegatively correlated with NSE and S100β levels. Conclusion: The increase of serum NSEand S100β levels in children with HFMD complicated by encephalitis is closely related toinflammatory response activation and immune response disorder.