Research progress in the influence of EGFR genovariation on the clinical efficacy of gefitinib treatment of non-small cell lung cancer

摘要

Objective: To study the correlation of Doppler ultrasound parameters with angiogenesis and cancer cell growth in endometrial cancer. Methods: Patients with endometrial cancer and fibroids who accepted surgical resection in the Central Hospital of Enshi Autonomous Prefecture between March 2015 and June 2017 were selected as the research subjects and enrolled in the observation group and control group of the study respectively. The preoperative pelvic Doppler ultrasonography was done to determine the blood flow parameters resistance index (RI) and pulsatility index (PI) of the endometrial lesions; after surgical resection, the endometrial cancer lesion tissue was collected from the observation group and normal endometrial tissue was collected from the control group to determine the contents of pro- proliferation molecules, pro-invasion molecules and angiogenesis molecules. Results: PI and RI levels in endometrial cancer lesion of observation group were significantly lower than those of control group, and cIAP1, cIAP2, RLIP76, p-Pak4ser474, EFEMP2, CXCR4, CXCR7, Snail, Septin-9, β-arrestin2 and SOX2 protein levels in endometrial cancer lesion were significantly higher than those of control group; PI and RI levels in endometrial cancer lesion were negatively correlated with cIAP1, cIAP2, RLIP76, p-Pak4ser474, EFEMP2, CXCR4, CXCR7, Snail, Septin-9, β-arrestin2 and SOX2 protein levels. Conclusion: The Doppler ultrasound parameters of endometrial carcinoma lesion are closely related to the angiogenesis and cancer cell growth in the lesion.