Correlation of intracranial artery calcification with atherosclerotic plaque properties and oxidative stress response in patients with lacunar infarction

摘要

Objective: To study the correlation of intracranial artery calcification with atherosclerotic plaque properties and oxidative stress response in patients with lacunar infarction. Methods: Patients who were diagnosed with lacunar infarction in the hospital between June 2014 and April 2017 were selected as the LI group of the research, and CTA was conducted to judge the intracranial calcification degree; healthy subjects who received physical examination in the Third People's Hospital of Chengdu during the same period were selected as the control group of the research. Serum was collected from the two groups to determine the plaque properties and the oxidative stress response-related biochemical index levels. Results: Serum Hcy, hs- CRP, MMP3, MMP9, ox-LDL, ET and TRAIL levels of LI group were greatly higher than those of control group whereas NO and MT levels were greatly lower than those of control group; serum Hcy, hs-CRP, MMP3, MMP9, ox-LDL, ET and TRAIL levels of LI group of patients with mild calcification and severe calcification were greatly higher than those of patients without calcification whereas NO and MT levels were greatly lower than those of patients without calcification, and serum Hcy, hs-CRP, MMP3, MMP9, ox-LDL, ET and TRAIL levels of LI group of patients with severe calcification were greatly higher than those of patients with mild calcification whereas NO and MT levels were greatly lower than those of patients with mild calcification. Conclusion: The increase of intracranial artery calcification in patients with lacunar infarction is closely related to the changes of atherosclerotic plaque properties and the activation of oxidative stress response.