The correlation of insulin resistance with the cerebral injury and stress reaction in patients with traumatic brain injury

摘要

Objective: To study the correlation of insulin resistance with the cerebral injury and stressreaction in patients with traumatic brain injury (TBI). Methods: 78 patients who werediagnosed with acute traumatic brain injury in our hospital between May 2014 and August2016 were selected as the TBI group, and 90 healthy volunteers who received physicalexamination during the same period were selected as the control group. The peripheral bloodwas collected to detect glucose, insulin and nerve injury marker molecules, stress hormonesas well as oxidative stress reaction products, and the insulin resistance index (HOMA-IR) wascalculated. Results: The HOMA-IR index of TBI group was significantly higher than that ofcontrol group (P0.05); serum neuron-specific enolase (NSE), ubiquitin carboxy-terminalhydrolase L1 (UCH-L1), S100β, myelin basic protein (MBP), glucagon, growth hormone,cortisol, malondialdehyde (MDA) and 8-hydroxy-deoxyguanosine (8-OHdG)levels of TBIgroup were significantly higher than those of control group (P0.05); serum NSE, UCH-L1,S100β, MBP, glucagon, growth hormone, cortisol, MDA and 8-OHdG levels of patients withhigh HOMA-IR were significantly higher than those of patients with low HOMA-IR (P0.05).Conclusion: The insulin resistance increases significantly in patients with traumatic braininjury, and is closely related to the degree of cerebral injury and stress reaction.