Diagnostic value of MicroPure imaging for malignant thyroid nodule microcalcification and its correlation with the oncogene expression in nodules

摘要

Objective: To study the diagnostic value of MicroPure imaging for malignant thyroid nodulemicrocalcification and its correlation with the oncogene expression in nodules. Methods:Patients with thyroid nodules confirmed by ultrasound in Dongtai People's Hospital betweenJune 2014 and October 2016 were selected and divided into those with malignant thyroidnodules and benign thyroid nodules according to the pathological results, and MicroPureimaging technology was used to judge the microcalcification and further divide the malignantthyroid nodules into microcalcification (+) and microcalcification (-). The biopsy tissuewas collected to detect the expression of cyclin, cell invasion molecules and angiogenesismolecules. Results: CyclinD1, CyclinE, MCM7, MMP2, MMP13, Vimentin, N-cadherin,Twist, HIF-1α, VEGF-C,VEGFR-2, VEGFR-3, Ang-2 and Tie-2 expression in malignantthyroid nodules of microcalcification (+) group and microcalcification (-) group weresignificantly higher than those of benign group while CyclinG2 and P53 expression weresignificantly lower than those of benign group; CyclinD1, CyclinE, MCM7, MMP2, MMP13,Vimentin, N-cadherin, Twist, HIF-1α, VEGF-C, VEGFR-2, VEGFR-3, Ang-2 and Tie-2expression in malignant thyroid nodules of microcalcification (+) group were significantlyhigher than those of microcalcification (-) group while CyclinG2 and P53 expression weresignificantly lower than those of microcalcification (-) group. Conclusion: Malignant thyroidnodule microcalcification detected by MicroPure imaging has a good correlation with cancercell proliferation, invasion and angiogenesis.