Effect of trimetazidine in combined with Huangqi injection in resisting inflammation and oxygen radicals in patients with acute viral myocarditis

摘要

Objective: To explore the effect of trimetazidine in combined with Huangqi injection in resisting inflammation and oxygen radicals in patients with acute viral myocarditis (AVMC). Methods: A total of 70 patients with AVMC who were admitted in our hosptial from October, 2015 to September, 2017 were included in the study and randomized into the observation group and the control group with 35 cases in each group. The patients in the control group were orally administrated with trimetazidine. On the above basis, the patients in the observation group were given intravenous injection of Huangqi injection. The patients in the two groups were treated for 4 weeks. The morning fasting peripheral venous blood before and after treatment was collected. The serum TFN-α, IL-6, CRP, MDA, SOD, NO, cTnI, CK, CK-MB, and LDH. Results: CRP, TFN-α, and IL-6 after treatment in the observation group were significantly lower than those in the control group. MDA and NO after treatment in the observation group were significantly lower than those in the control group, while SOD was significantly higher than that in the control group. cTnI, CK, CK-MB, and LDH after treatment in the observation group were significantly lower than those in the control group. Conclusions: Trimetazidine in combined with Huangqi injection in the treatment of AVMC can effectively play the anti-inflammation and anti-OFR effects in order to reduce the myocardial damage, thus, the therapeutic effect is enhanced.