Protective Effect of Aerial Parts of Portulaca oleracea and Ficus carica Leaves Against Diclofenac-Sodium Induced Hepatotoxicity in Rats

摘要

The present experiment is aimed to evaluate the hepatoprotective effects of purslane (PuE) and fig leaves (FlE) extracts on diclofenac-sodium (DS) induced hepatotoxicity in rats. Adult male rats were pretreated orally with PuE and FlE extracts at a dose of 10ml/kg and 200mg/kg body weight, respectively for 14 days. Co-treatment of DS 16mg/kg body weight was given orally for 7days. The present results demonstrated that the treatment with PuE and FlE combination with DS induced a marked improvement in the studied parameters. Data indicated that there were no significant differences in relative liver weight (RLW) and relative kidney weight (RKW) in group treated with PuE and FlE and/or their combination as compared to control. Plasma liver enzyme activities as well as bilirubin levels were increased in the groups receiving diclofenac only or in combination as compared with control group. However, the administration of PuE and FlE ameliorated DS induced hepatotoxicity by improving antioxidant status, decreasing inflammation, lowering TBARS and weakening the adverse effect of diclofenac on hepatic tissues. Liver injury was confirmed by the histological changes. Taken together, the present study concluded that enhancement of antioxidants and promising activity against diclofenac-induced hepatotoxicity may a result for the effect of PuE and FlE.