Effect of Canarium Schweinfurthii and Dacryodes Edulis Oils on Blood Lipids, Lipid Peroxidation and Oxidative Stress in Rats

摘要

The aim of this study was to compare the effects of two vegetable oils on the growth, blood lipids, lipid peroxidation and oxidative stress in rats. One month old male rats Sprague Dawley were fed during 60 days with a diet containing Canarium schweinfurthii oil (CSO group), or Dacryodes edulis oil (DEO group), or palm oil (PO group). Palm oil was used as control. On 6 rats before the experimentation (baseline group) and on rats fed different diets, serum were used for total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, glycerol, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubine determinations. Plasma were used for fatty acids, selenium and malondialdehyde determination. Glutathione peroxydase and superoxyde dismutase were measured in red blood cells. The daily food intake was different from one group to another.During the first month of the experiment, CSO diet was the most consummed. The gain in body weight was highest for the PO group. This group presents a high value of triglycerides, glycerol and asparatate aminotransferase compare to CSO and DEO groups. HDL-cholesterol, creatinine, alaninine aminotransferase, alkaline phosphatase, total bilirubine malondialdehyde and selenium level was not significantly different (p<0.05) for rats fed PO, CSO and DEO diets. Oils experimented contribute to the decrease the LDL-cholesterol level for over 50% in comparison of the baseline group. The atherogenicity index is highest for baseline group than PO, CSO and DEO groups. Oils experimented influenced glycerol, alanine aminotransferase level. We can conclude that oils experimented decrease the risk factor of cardiovascular disease to 43.91% for CSO and DEOgroups and to 39.30% for PO group.