A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

摘要

Background Metabolic syndrome (MeS) is being recognized as a risk factor for insulin resistance and cardiovascular disease. The present study was aimed to find out the possible association between 45-bp I/D polymorphism of uncoupling protein 2 (UCP2) and MeS. Methods DNA was extracted from peripheral blood of 151 subjects with and 149 subjects without MeS. 45-bp I/D variant of UCP2 was detected using polymerase chain reaction (PCR). Results Our finding showed that 45-bp I/D polymorphism was associated with protection against MeS (OR?=?0.56, 95%?CI?=?0.34-0.92, p?=?0.020 D/I vs DD and OR?=?0.54, 95%?CI?=?0.34-0.86, p?=?0.009; D/I + I/I vs D/D). The I allele decreased the risk of MeS (OR?=?0.62, 95%?CI?=?0.44-0.90, p?=?0.011) in comparison with D allele. Conclusion In conclusion, our result suggests that 45-bp I/D polymorphism is associated with the risk of MeS, which remains to be cleared.