Development and Characterization of Core Shell Nanoparticle for Enhanced Drug Delivery to Treat Solid Tumor: Preparation and In-Vitro Assessment

摘要

Mortalities from cancer in the world are projected to continue rising, with an estimated 9 million and 11.4 million people dying from cancer in 2015 and 2030, respectively. Rates are rising as more people live to an old age and as mass lifestyle changes occur in the developing world. With present treating regimen for cancer, dose-limited toxicity is a big reason that reduces the efficacy of cancer treatments. In search for more effective cancer treatments, nanosized drug delivery systems, those are capable of delivering their drug payload selectively to cancer cells such as nanoparticles, solid lipid nanoparticles, liposomes are among the most promising approaches. Core shell nanoparticles are one of the investigated moieties in recent years that are seeking much attention nowadays for biomedical applications including the field of oncology.The present work aims at developing a core shell nanoparticle comprising Poly (D, L –lactide –co –glycolide) (PLGA) core and polyethyleneimine (PEI) shell loaded with anticancer bioactive docetaxel (DTX) for passive targeting of the tumor tissue. It is expected that incorporation of PEI will improve the uptake and subsequent release of the drug in the cytosol due to endosomal escape phenomenon.