Preparation of pH sensitive calcium phosphate/SiO_2 core-shell nanoparticle for drug delivery

摘要

In summary, calcium phosphate / silicon dioxide core-shell nanoparticlewith spherical shapeand small size are prepared sucessfully in a simple, inexpensive, one-step procedure. The calcium phosphate core can dissolve rapidly at acid condition causing the endosome bursting. The silica shell can slow down the drug release protecting the drug from being degradated. The pH-sensitive core-shell nanoparticles may be efficient drug carriers without the drawback of cytotoxicity, in comparison with some positively charged vesicles.