Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents

摘要

A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (~1H and ~(13)C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.