FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF PERINDOPRIL ERBUMINE USING NATURAL SUPERDISINTEGRANT

摘要

Oral disintegrating tablets are emerging trend in Novel drug delivery system & received increasing demand & popularity due to ease of administration & better patient compliance .In recent years superdisintegrant have been employed to develop effectual mouth dissolving tablet & to overcome limitation of conventional tablets .In present study attempt was made to compare to disintegrating efficiency of natural superdisintegrats .Main aim of using oscimum basilicum as natural superdisintegrant was to achieve quick onset of action ,increases water uptake with short wetting time & decreasing disintegration time by cost effective direct compression method. 3 preliminary batches were prepared & these are evaluated for precompression parameter like angle of repose, carr`s index & post compression parameters like wetting time, water absorption ratio,in vitro disintegration. Hardness, friability of all formulations found within limit. Best formulation F2 batch had shown good hardness, friability, disintegration time, swelling time. Present study revealed that mucilage obtained from oscimum basilicum was effective for their disintegrating property.