Hypothyroidism Relationship with Non-Alcoholic Fatty Liver Disease: A Meta-Analysis

摘要

Thyroid hormones play an important role in the regulation of body weight, lipid metabolism and insulin resistance. Therefore, it is predictable that thyroid hormones may play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this study, we reviewed the all current research articles and literatures on the association between hypothyroidism (thyroid dysfunction) and NAFLD/NASH. In this study, we conducted a meta-analysis using a comprehensive search of PubMed, MEDLINE, EMBASE, Scopus, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trails till April 2019 for evaluating the relationship between hypothyroidism (thyroid dysfunction) and non-alcoholic fatty liver disease. Sixteen studies were included in the present meta-analysis. The present meta-analysis provides strong epidemiological evidence for the relationship between hypothyroidism and NAFLD. Both individuals with sub-clinical hypothyroidism and overt hypothyroidism are at higher risk for NAFLD than euthyroid subjects.