Protective role of Carica papaya and Ficus bengalensis latex against CCl4 induced liver toxicity in experimental rats

摘要

Objective: To study the hepatoprotective activity of Carica Papaya Latex at the dose 400mg/kg/b.w. per oral and Ficus Bengalensis latex at dose 300mg/kg/b.w. per oral against CClsub4/sub induce Hepatotoxicity in albino rats. Method: Animals were divided into 5 groups of 6 animals in each group. Group I – Served as a normal control received saline 1ml /Kg for 21 days. The group -II, III, IV and V animals were received CClsub4/sub at dose 1ml/Kg b.w./day intra- peritoneally. Animals from group –III to V received Carica Papaya Latex (400mg/Kg.p.o.), Ficus Bengalensis Latex (300mg/Kg.p.o.) and standard drug Silymarin (30mg/Kg.p.o.) once daily for 21 days. All groups animals were sacrificed on 22 days under light ether anesthesia . Blood sample were collected and used for bio-chemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), Bilirubin(BRN), Alkaline phosphate (ALP) and total protein. Result :The results were observed that Carica Papaya latex at dose 400 mg/kg.b.w and CClsub4 /subtreated group , Ficus Bengalensis latex at dose 300 mg/kg.B.w and CClsub4 /subtreated groups were found the decreased levels of SGPT,SGOT,, ALP and Bilirubin and increased total protein level compare to CClsub4/sub treated group .So that this study indicated hepatoprotective effect . Conclusion : Present investigation indicated that both latex of Carica papaya and Ficus Bengalensis showed significant protection against CClsub4/sub nduced hepatotoxicity in Rats.