DENDRIMER: A NOVEL DRUG DELIVERY SYSTEM

摘要

Dendrimer as a drug delivery system is based on the approach of sending a nano particle (10 -9 ) to the body, loaded with drug. The drug might be loaded on its terminal surface or encapsulated within the branches of a dendrimer. It’s very small size and unique properties like polyvalency, monodispersity, stability make it an appropriate carrier for delivering drugs with precision and selectivity. Dendrimers help in achieving increased bioavailability, sustained, controlled as well as targeted release of drug. There is reduction in the amount of drug and systemic toxicity while the therapeutic efficacy increases. It is advancing as a method used for delivery of various drugs like anticancer drugs(methotrexate), drug for prevention of HIV, enhancing bioavailability of pilocarpine for ocular drug delivery, et al. This approach as a drug delivery system certainly promises a reliable, safe, selective and precise method of drug delivery