Ischemia modified albumin and nitric oxide in diabetic nephropathy

摘要

Diabetes is associated with complications related to ischemia and oxidative stress. Diabetic nephropathy is one of the common vascular complications. The aim of the study was to evaluate the levels of ischemia modified albumin and nitric oxide in patients with diabetic nephropathy. Serum levels of ischemia modified albumin and nitric oxide were estimated in fifty patients with diabetic nephropathy and fifty patients with uncomplicated diabetes along with routine biochemistry investigations and compared with thirty healthy controls. The correlation of micoalbuminuria with ischemia modified albumin and nitric oxide was also calculated in patients with diabetic nephropathy. The levels of ischemia modified albumin and nitric oxide were found to be raised (p < 0.001) in patients with diabetic nephropathy as compared to uncomplicated diabetes and healthy controls. A positive correlation of these parameters was observed with microabuminuria. Thus, estimation of ischemia modified albumin and nitric oxide may help in better understanding of etiopathogenesis of diabetic nephropathy and may act as markers for this condition, if supported by further research.