Drug-dietary interaction potential of garlic on glimepiride treated type 2 diabetic Wistar rats

摘要

The present study evaluates the drug dietary interaction potential of garlic with glimepiride. Type 2 diabetes mellitus was induced in overnight fasted wistar rats by streptozotocin and Nicotinamide. Six groups of rats viz. group 1(normal control), group 2 (diabetic control), group 3(standard) and groups 4, 5 and 6 (groups having standard drug glimepiride with aqueous extract of garlic i.e. 125 mg/kg, 250 mg/kg and 500 mg/kg body weight respectively) were employed in the study and each group contained seven animals. Blood glucose, cholesterol, triglycerides and HDL levels were estimated from 1st day to 28th day and statistically significant hypoglycaemic and anti-hyperlipidaemic effects seen with co-administration of glimepiride and garlic at a dose of 250 mg/kg and 500 mg/kg body weight as compared to glimepiride alone (p < 0.05). There were slight increases in HDL levels, however these were not statistically significant compared to the first day values. This study revealed that a drug interaction also provides some beneficial effects. As in this study; use of glimepiride with garlic treatment not only resulted in tight glycaemic control in diabetic rats but also provide beneficial hypolipidaemic effect, closely related to diabetes progression.