Ease of Use of Two Reusable, Half-Unit Increment Dosing Insulin Pens by Adult Caregivers of Children with Type 1 Diabetes: A Randomized, Crossover Comparison

摘要

I nsulin pens deliver accurate doses, which are important for children who require low doses and are at risk for hypoglycemia. 1 Reusable insulin pens that deliver insulin in half-unit (U) increments include HumaPen ? Luxura? HD (Eli Lilly and Company, Indianapolis, IN; insulin lispro injection, 0.5 to 30 units; Pen A) and NovoPen ? Junior (Novo Nordisk A/S, Bagsvaerd, Denmark; insulin aspart injection, 1 to 35 U; Pen B). The purpose of this randomized, 2-period, crossover, open-label, simulated injection study was to compare the functional usability and preference of these pens in 65 adult caregivers of children aged 3–12 years with type 1 diabetes. The caregivers’ pen preferences were assessed for overall ease of use as the primary end point and for ease of changing the insulin cartridge and ease of correcting the insulin dose as the secondary end points.