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Design, Characterization and In-vitro Evaluation of Superporous Hydrogel Tablets of Nimodipine

机译:尼莫地平超孔水凝胶片的设计,表征及体外评价

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The present work was aimed to formulate Superporous Hydrogel tablets of Nimodipine using an effervescent approach for gastro retentive drug delivery system to improve its bioavailability by using different rate retarding polymers like plantago ovata, tamarind gum and carbopol, along with suitable excipients. All the formulations were prepared by direct compressionmethod. The prepared tablets of all the formulations were evaluated for physical characteristics, in‐vitro drug release, hardness and friability. Optimized formulation F8 containing 0.3% of plantago ovata and carbopol each was considered as the best formulation with respect to in vitro drug release for 12 hours release action. The results showed that the drug release rate was decreased as the viscosity of the polymer was increased. The drug release kinetics was performed for the optimized formulation and it shows zero orderwith non-fickian transport drug release.
机译:本工作旨在通过泡腾的方法来制备尼莫地平超孔水凝胶片,用于胃滞留药物递送系统,以通过使用不同的速率降低性聚合物(如车前子,卵,罗望子树胶和卡波姆)以及合适的赋形剂来提高其生物利用度。所有制剂均通过直接压缩法制备。对所有制剂中制备的片剂进行了物理特性,体外药物释放,硬度和脆性的评估。就体外药物释放12小时释放作用而言,分别包含0.3%的车前子卵和卡波姆的优化制剂F8被认为是最佳制剂。结果表明,随着聚合物粘度的增加,药物的释放速率降低。对优化的配方进行了药物释放动力学,结果显示非零转运药物释放为零级。

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