Evaluation of the effects of isotretinoin for treatment of acne on corneal sensitivity

摘要

PurposeTo determine the effect of isotretinoin on corneal sensitivity in acne patients.MethodsFifty patients (13 men and 37 women) with a mean age of 23.24?±?3.4 years were selected among patients receiving isotretinoin (1.0?mg/kg) for acne according to inclusion criteria. The Cochet-Bonnet esthesiometer was used to measure corneal sensitivity (in mm filament length) two times (the measurements were done immediately before starting the medication, then 3 months after that), including 3 measurements each time, between 11 a.m. and 1 p.m. by an experienced operator. The average of the 3 measurements in each time was recorded as the final value. One-way analysis of variance and Chi square were used for quantitative and qualitative comparison of corneal sensitivity before and after isotretinoin use, respectively.ResultsThe mean corneal sensitivity was 5.54?±?0.05 before medication consumption which decreased to 5.41?±?0.05 after isotretinoin treatment for 3 months (P?