Clinical significance of serum IGFBP‐3 in colorectal cancer

摘要

Background IGF‐binding protein 3（IGFBP‐3）has previously been identified as tumor marker. The present study aimed to investigate the clinical significance of serum IGFBP‐3 in colorectal cancer (CRC). Methods Serum was collected from 70 CRC patients and 50 healthy volunteer controls. Serum IGFBP‐3 and carcinoembryonic antigen (CEA) levels were measured using electrogenerated chemiluminescence immunoassay and compared between groups. Relationships between serum IGFBP‐3 level and the clinical characteristics of CRC were also analyzed. A receiver operator characteristic (ROC) curve was plotted to investigate diagnostic efficacy of serum IGFBP‐3 and CEA, respectively, for CRC. Data were analyzed using SPSS 13.0. Results Serum IGFBP‐3 levels in CRC were lower than those of controls (4.68 [3.56, 5.77] vs 5.44 [4.77, 6.10]?μg/mL, P Conclusions Serum IGFBP‐3 might be a potential biomarker for CRC.