Detecting autoantibodies to MAP4K4, IGFBP3, p53 and IGFBP2 in colorectal cancer patients

摘要

The invention relates to a method of detecting autoantibodies related to colorectal cancer in an individual comprising contacting a test sample from an individual with one or more target antigens selected from MAP4K4 and IGFBP3 and detecting any antibodies that bind to said antigens. The sample may also be contacted with target antigens selected from p53 or IGF2BP2 to detect autoantibodies to said antigens. Also provided in a further embodiment is a method for identifying antibodies related to cancer by comparing gene expression levels of cancer cells compared to normal cells, assaying body fluid from an individual with cancer for antibodies to the genes only activated in the cancer cells and identifying an antibody.