Serum pentraxin‐3 levels and flow‐mediated dilation in dipper and non‐dipper hypertension

摘要

Background Endothelial dysfunction is one of the main pathological processes of hypertension. The association of serum pentraxin‐3 (PTX3) levels and endothelial dysfunction becomes a more interesting scientific research issue due to high potential of PTX3 as a diagnostic and prognostic biomarker. We aimed to investigate the relationship between serum PTX3 levels and flow‐mediated dilation results in patients with dipper and non‐dipper hypertension. Methods This study included 90 hypertensive patients were divided into two groups based on 24?hours ambulatory blood pressure monitoring (ABPM): 38 patients with a dipper pattern and 52 patients with non‐dipper pattern. Noninvasive evaluation of the endothelial functions was performed using flow‐mediated dilation (FMD) method. Results Serum pentraxin‐3 levels were higher in patients with non‐dipper HT compared to dipper hypertension ( P =?0.028). In addition, we found negative correlation between serum PTX3 and FMD basal/FMD hyperemia ratio ( r =??0.297, P =?0.05 for FMD basal/FMD hyperemia ratio, respectively). Conclusions Serum PTX3 levels are closely related with the measures of indirect noninvasive evaluation methods (FMD) in both DH and NDH patients.