Liver stiffness assessed by transient elastography as a potential indicator of chronic kidney disease in patients with nonalcoholic fatty liver disease

摘要

Background This study was designed to determine the diagnostic value of liver stiffness measured by transient elastography (TE) in identifying chronic kidney disease (CKD) in individuals with ultrasonography‐diagnosed NAFLD. Methods A total of 1439 adult patients with ultrasonography‐diagnosed NAFLD between October 2015 and August 2017 in China‐Japan union hospital of Jilin university were initially eligible. According to the exclusion criteria, 24 patients were excluded, and eventually, a total of 1415 patients were included in the study. The AST/ALT ratio and FIB‐4 score were calculated from blood tests, and liver stiffness was measured using TE. Results The liver stiffness measured by TE, FIB‐4 score, ALT/AST ratio were significantly elevated in CKD patients, compared with those without CKD ( P Conclusions Liver stiffness assessed by TE is a potential indicator for CKD in ultrasonography‐diagnosed NAFLD patients. Further, a four‐variable model (liver stiffness, age, serum uric acid, and diabetes mellitus) could be a useful tool for identifying subjects at high risk for CKD in NAFLD patients.