Predictive value of serum pregnancy‐associated plasma protein A for patients with ischemic cerebrovascular disease

摘要

BackgroundTo investigate the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease. MethodsWe analyzed the levels of PAPP-A in the transient ischemic attack (TIA) patients, ischemic stroke (IS) patients and normal control, and followed up the outcome of the patients in the following 2?years. Blood samples were drawn at admission, prior to treatment with heparins. ResultsThe levels of PAPP-A in TIA patients, IS patients and normal control were 4.91 (2.11, 6.48) mIU/L, 6.77 (3.31, 10.23) mIU/L and 4.25 (1.76, 5.22) mIU/L, respectively. The follow-up results of TIA patients and IS patients indicated the PAPP-A concentration in the poor prognosis group were higher than those in the good prognosis group (5.90 vs 4.46?mIU/L, P ConclusionsHigher PAPP-A concentration has a forecasting value on prognosis in ischemic cerebrovascular disease.