Histopathological changes in the rat liver and kidney with references to nicotine toxicity

摘要

Nicotine, the principal alkaloid in tobacco, induces a cellular damage on heart and cardiomyocyte culture. The present study was undertaken to investigate the effects of green tea and guduchi extracts on nicotine-induced alterations in some organs of adult male mice (liver and kidney) by using histopathological studies. A total of 36 mice were divided into six groups For histopathological studies. Liver and kidney were excised from both control and experimental mice sacrificed on 60supth/sup day. Statistical analysis was performed for comparison between the groups by using Dunnett’s test. There was decreased inflammatory infiltration and intracellular edema in histology of renal tissue from green tea and guduchi extracts treated mice reflected a reduction in nicotine-induced renal damage. The histopathological examination of liver clearly revealed that the Hepatic Cells, Intact nucleus, and Central Vein, portal triad were almost normal in other groups in contrast to group which received inducer but with mild Kupffer cell hyperplasia.The results of present work suggested that green tea and guduchi extracts has a promising prophylactic effect against nicotine-induced oxidative damage of liver and kidney.