COMPARATIVE STUDY OF PHENYTOIN SODIUM AND ETHANOLIC EXTRACT OF NARDOSTACHYS JATAMANSI AUGMENTED WITH PHENYTOIN SODIUM TO EVALUATE ANTI-EPILEPTIC ACTIVITY OF THE DRUG

摘要

Epilepsy is a disorder of nervous system which leads to episodes of sensory interruption, loss of perception, or seizures , coupled with irregular electrical bustle in the brain. It is generally treated by drug therapy using anti-epileptic drugs. The core objective of this study is to comparatively study anti-epileptic activity of phenytoin sodium and ethanolic extract of jatamansi augmented with phenytoin sodium. Convulsions were induced in the mice by pentylenetetrazol?(PTZ) seizure model and maximal electroshock seizure (mes) model. Jatamansi extract augmented with phenytoin sodium was the drug used for the comparative study the anti-epileptic activity of phenytoin sodium. And jatamansi extract augmented with phenytoin sodium gave better results.