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Sleep Quality, Sleep Duration, and the Risk of Coronary Heart Disease: A Prospective Cohort Study With 60,586 Adults

机译:睡眠质量,睡眠时间和冠心病风险:一项针对60,586名成年人的前瞻性队列研究

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Study Objectives There is limited information on the relationship between risk of cardiovascular disease and the joint effects of sleep quality and sleep duration, especially from large, prospective, cohort studies. This study is to prospectively investigate the joint effects of sleep quality and sleep duration on the development of coronary heart disease.Methods This study examined 60,586 adults aged 40 years or older. A self-administered questionnaire was used to collect information on sleep quality and sleep duration as well as a wide range of potential confounders. Events of coronary heart disease were self-reported in subsequent medical examinations. Two types of Sleep Score (multiplicative and additive) were constructed to reflect the participants' sleep profiles, considering both sleep quality and sleep duration. The Cox regression model was used to estimate the hazard ratio (HR) and the 95% confidence interval (CI).Results A total of 2,740 participants (4.5%) reported new events of coronary heart disease at follow-up. For sleep duration, participants in the group of 6 h/d was significantly associated with an increased risk of coronary heart disease (HR: 1.13, 95% CI: 1.04–1.23). However, the association in the participants with long sleep duration ( 8 h/d) did not reach statistical significance (HR: 1.11, 95% CI: 0.98–1.26). For sleep quality, both dreamy sleep (HR: 1.21, 95% CI: 1.10–1.32) and difficult to fall asleep/use of sleeping pills or drugs (HR: 1.40, 95% CI: 1.25–1.56) were associated with an increased risk of the disease. Participants in the lowest quartile of multiplicative Sleep Score (HR: 1.31, 95% CI: 1.16–1.47) and of additive sleep score (HR: 1.31, 95% CI: 1.16–1.47) were associated with increased risk of coronary heart disease compared with those in the highest quartile.Conclusions Both short sleep duration and poor sleep quality are associated with the risk of coronary heart disease. The association for long sleep duration does not reach statistical significance. Lower Sleep Score (poorer sleep profile) increases the risk of coronary heart disease, suggesting the importance of considering sleep duration and sleep quality together when developing strategies to improve sleep for cardiovascular disease prevention.
机译:研究目标有关心血管疾病风险与睡眠质量和睡眠时间的联合影响之间关系的信息有限,尤其是来自大型,前瞻性队列研究的数据。这项研究是前瞻性研究睡眠质量和睡眠时间对冠心病发展的联合影响。方法这项研究调查了60,586名40岁以上的成年人。使用自我管理的问卷来收集有关睡眠质量和睡眠时间以及各种潜在混杂因素的信息。冠心病的事件在随后的医学检查中自行报告。考虑到睡眠质量和睡眠时间,构建了两种类型的睡眠得分(乘法和累加)以反映参与者的睡眠状况。使用Cox回归模型估算危险比(HR)和95%置信区间(CI)。结果共有2740名参与者(4.5%)报告了随访时发生的冠心病新事件。对于睡眠时间,<6 h / d组的参与者与冠心病风险增加显着相关(HR:1.13,95%CI:1.04–1.23)。然而,睡眠时间长(> 8 h / d)的参与者的关联性未达到统计学显着性(HR:1.11,95%CI:0.98–1.26)。对于睡眠质量,梦幻睡眠(HR:1.21,95%CI:1.10–1.32)和难以入睡/使用安眠药或药物(HR:1.40,95%CI:1.25–1.56)均与睡眠质量增加有关。患病的风险。与乘法睡眠评分最低的四分位数(HR:1.31,95%CI:1.16-1.47)和加性睡眠评分(HR:1.31,95%CI:1.16-1.47)的参与者相比,冠心病的风险增加结论睡眠时间短和睡眠质量差都与冠心病的风险有关。长时间睡眠的关联没有达到统计学意义。较低的睡眠得分(较差的睡眠状况)会增加患冠心病的风险,这表明在制定预防心血管疾病的改善睡眠策略时,必须同时考虑睡眠时间和睡眠质量。

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