Pentafluorophenylammonium triflate-CuCl2: A mild, efficient and reusable heterogeneous catalyst system for facile synthesis of 4(3H)-quinazolinones under solvent-free conditions

摘要

Pentafluorophenylammonium triflate (PFPAT) was found to be highly efficient, and recyclable heterogeneous catalyst for the synthesis of 4(3H)-quinazolinones by cyclocondensation reaction of 2-aminobenzamide with aryl aldehydes in the presence of CuCl2 as co-catalyst in good to excellent yields under solvent-free conditions. The present methodology offers several advantages, such as simple procedure with an easy work-up, high yields, short reaction times, and the absence of any volatile or hazardous organic solvents. Moreover, the catalyst can be easily recovered and reused at least three times with only slight reduction in its catalytic activity.