The effect of intravenous iron therapy on total antioxidant capacity in patients with iron deficiency anemia

摘要

Objectives: Parenteral iron is used for patients who are either unable to absorb oral iron or who have increasing anemia despite adequate doses of per oral iron. Paren-teral iron preparations are clearly effective, but concerns have been raised regarding adverse events and poten-tially long-term toxicity. So, in this study we aimed to in-vestigate the effect of intravenous iron therapy on acute antioxidant capacity.Materials and methods: Totally 36 patients with iron de-ficiency anemia and 20 healthy controls were included in the study. Prior to iron infusion to subjects, blood samples were obtained for measurement of total antioxidant ca-pacity. Then patients received 100 mg intravenous iron sucrose in an hour. And at the first hour after the infusion was completed, the blood samples were repeated.Results: Before the treatment total antioxidant capac-ity was significantly lower in anemic patients (280±34 μmol/L) than in control group (365±58 μmol/L) (p=0.001). Significantly decreased total antioxidant capacity (264±35 μmol/L) was found after the iron treatment (p=0.01). No adverse events related to intravenous iron were ob-served.Conclusion: In this study, we observed that intravenously administered iron sucrose in 100 mg dose and also iron deficiency anemia itself, caused increased oxidative stress