Multipl skleroz hastalar?nda otonom sinir sistemi ile ili?kili sempatik cilt yan?tlar?n?n de?erlendirilmesi ve yorgunluk skorlar? [Sympathetic skin responses associated with the autonomic nervous system and fatigue scores in patients with MS]

摘要

Objectives:In this study we aimed to investigate the ef-fect of autonomic dysfunction on quality of life and symp-toms of fatigue patients with MS.Materials and methods: The study included 30 patients with MS and 35 healthy subjects as control group. Dis-ability was assessed using the Expanded Disability Sta-tus Scale (EDSS); autonomic functions were assessed by SSR; fatigue symptoms were assessed by Fatigue Descriptive Scale (FDS); effect of autonomic dysfunction on quality of life and fatigue symptoms was assessed by SF-36 scale.Results:There was no significant difference between the left hand SSR latency, mean amplitude and area between patient and control groups. Mean FDS value was signifi-cantly higher in MS group. SSR amplitude and area were significantly smaller in patients which received prophy-lactic treatment. There was no relation between the FDS scores and SSR values in patients receiving prophylaxis. In the patient group, a positive correlation was detected between EDSS and FDS score; and significantly negative correlation between pyramidal, cerebellar and spasticity; a significant positive correlation was found between am-plitude and the size of area of the SSR and brain stem functions. There was no significant relationship between FDS with SSR area, latency and amplitude. Conclusions:SSR measurements are not sensitive in order to evaluate autonomic dysfunction in patients with multiple sclerosis. Symptoms of fatigue has a negatively affect on the activity of the patient's daily life. SSR test is not sufficient to show the relationship between fatigue and autonomic dysfunction