Long noncoding RNA activated by transforming growth factor-β promotes cancer development and is a prognostic marker in cervical cancer

摘要

Background: Long noncoding RNAs (lncRNAs) have been highlighted as crucial elements in cancer biology. LncRNA activated by transforming growth factor-β (ATB) was identified to promote the development of multiple cancers and may serve as a potential therapeutic target in human cancers. However, to the best of our knowledge, the functional role of ATB in cervical cancer has not been verified yet. Materials and Methods: The expression of lncRNA ATB was evaluated by quantitative reverse transcriptase-polymerase chain reaction assay in cervical cancer cell lines and clinical specimens. The clinical significance of ATB was statistically evaluated by analyzing the relationship between ATB overexpression and the clinicopathological characteristics of cervical cancer patients. Moreover, Kaplan–Meier analysis and log-rank test were conducted to investigate the role of ATB in the overall survival (OS) and progression-free survival (PFS) of cervical cancer patients or subgroup patients. Furthermore, univariate and multivariate analyses were adopted to identify the risk factors of OS and PFS of cervical cancer patients. Results: LncRNA ATB was upregulated in cervical cancer cell lines and tissues (P P P P Conclusion: LncRNA ATB correlates with the malignant phenotypes and poor prognosis of cervical cancer. ATB may serve as a promising prognostic marker and therapeutic target of cervical cancer patients.