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首页> 外文期刊>Journal of Biosciences and Medicines >The Preventative Effect of Dietary Apostichopus japonicus on Intestinal Microflora Dysregulation in Immunosuppressive Mice Induced by Cyclophosphamide
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The Preventative Effect of Dietary Apostichopus japonicus on Intestinal Microflora Dysregulation in Immunosuppressive Mice Induced by Cyclophosphamide

机译:日粮刺参对环磷酰胺诱导的免疫抑制小鼠肠道菌群失调的预防作用

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摘要

Sea cucumbers are recognized as food and drug resources with many nutritional benefits, and Apostichopus japonicus is a kind of sea cucumber with good quality. Processing methods have some effect on its quality. This study aimed to explore the effects of Apostichopus japonicus with three different processing methods (dried, instant, and enzymatic sea cucummbers) on intestinal microflora dysregulation using a cyclophosphamide (cy) induced immunosuppressive mouse model. The expression of lysozyme, immunoglobulin A (IgA), and polymeric immunoglobulin receptor (pIgR) in the intestine and gut microbiota were investigated. The results showed that three types of A. japonicus could improve mucosal immunity and regulate gut microbiota. Dietary A. japonicus could reverse microbial imbalance, including increasing the bacterial diversity, enhancing the number of Bifidobacterium, and changing the bacterial composition. The most effect was observed with dried A. japonicus. Expression of lysozyme and IgA in the intestine was significantly increased. This study identified positive effects of dietary A. japonicus on mucosal immunity, particularly on gut microbiota, suggesting that dietary A. japonicus may aid in improving mucosal immunity and preventing exogenous infection. Additionally, the processing method has some effect on immunomodulatory function.
机译:海参被认为是具有许多营养价值的食品和药物资源,刺参是一种优质的海参。加工方法对其质量有一定影响。这项研究的目的是探索使用三种不同的加工方法(干燥,速溶和酶促海参)的刺槐(Apostichopus japonicus)对使用环磷酰胺(cy)诱导的免疫抑制小鼠模型引起的肠道菌群失调的影响。研究了在肠道和肠道菌群中溶菌酶,免疫球蛋白A(IgA)和聚合免疫球蛋白受体(pIgR)的表达。结果表明,三种类型的刺参可以提高粘膜免疫力和调节肠道菌群。日粮中的日本曲霉可以逆转微生物失衡,包括增加细菌多样性,增加双歧杆菌数量以及改变细菌组成。用干燥的日本刺参观察到最大的效果。肠中溶菌酶和IgA的表达显着增加。这项研究确定了日粮农杆菌对粘膜免疫,特别是对肠道菌群的积极影响,表明日粮农杆菌可能有助于提高粘膜免疫力和预防外源性感染。另外,该加工方法对免疫调节功能有一定影响。

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