Genotoxicity and Cytotoxicity of the Anticancer Drugs Gemcitabine and Cisplatin, Separately and in Combination: in vivo Studies

摘要

Both gemcitabine (2`,2`-difluorodeoxycytidine, dFdC) and cisplatin (cis-diammine-dichloroplatinum) have significant anticancer activity against ovarian, head and neck and non-small cell lung cancer (NSCLC). dFdC can be incorporated into DNA and RNA and in