Therapeutic Effect of White Cabbage ( Brassica oleracea ) Aqueous Extract on Hyperglycemia in Prediabetes-induced Male Albino Rats

摘要

Background and Objective: Some plant materials have been found to possess hypoglycemic property which could ameliorate hyperglycemic condition. Thus, this study aimed at determining the effect of cabbage on hyperglycemia. Materials and Methods: Extracts from fresh and dried cabbage and thirty male albino rats grouped into six groups were used for the study. The groups were the positive control (fed regular diet), negative control (fed high sucrose feed) and treatment (high sucrose feed and extract for 2 weeks) groups. Each of the treatment groups received 50 mg or 100 mg kgSUP?1/SUP b.wt., of either of fresh and dried cabbage extracts. The fasting blood sugar (FBS) was determined at baseline and at two weeks interval. The experiment lasted six weeks when the serum insulin, oral glucose tolerance test and liver oxidative stress were determined. Data were subjected to Graph pad prism 5 and the blood glucose was analyzed using analysis of variance (ANOVA) at pResults: There was a reduction in the blood sugar and resistance to insulin by the extracts. The control negative had the highest fasting blood sugar (62 mg dLSUP?1/SUP) and the result of oral glucose tolerance also showed higher peak at 60 min. There was a reduction in the MDA (0.54±0.08-0.79±0.05) accompanied by significant reduction in the SOD (0.52±0.04-0.57±0.04) and CAT (1.85±0.65-15.75±1.69) of the test groups. Conclusion: Potential of cabbage to control blood sugar and ameliorate oxidative stress of the liver was demonstrated in this study.