Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease

摘要

Aim: This study was conducted to investigate the role of chronic kidney disease (CKD) in 1-year allcause mortality and cardiovascular mortality among Chinese patients who were at least 50 years old and had a history of coronary artery disease (CAD), stroke, or peripheral vascular disease (PAD), or with two or more cardiovascular risks. Methods: Of 3,732 hospitalized patients enrolled, 3,423 patients (91.7%) with complete data were eligible for 1-year follow-up. CKD was defined as an estimated glomerular filtration rate (eGFR) of 2. Results: 1,166 (34.1%) were diagnosed with CKD. Most cases were unrecognized. Patients having an eGFR of 2 were less likely to be prescribed beta-blockers, statins, or aspirin (all p 2 was 1.70 (95% CI, 1.18-2.45) and 1.85 (95% CI, 1.12-3.01) as compared with 2.93 (95% CI, 1.96-4.38) and 3.47 (95% CI, 1.91-6.31) for patients with an eGFR of 2. Conclusions: One third of Chinese patients at high risk for atherosclerotic events were diagnosed with CKD. Most of these cases were unrecognized and undertreated. An eGFR of 2 was an independent predictor of all causes of death and of cardiovascular death.