RISK MARKERS FOR CARDIOVASCULAR DISEASES IN PATIENTS WITH CHRONIC KIDNEY DISEASE

摘要

FIELD: biotechnology.;SUBSTANCE: method for assessing the risk of cardiovascular events in a subject, comprising steps of determining in a sample isolated from said subject suffering from chronic kidney disease the presence of a polymorphism at position 27 in nucleic acid sequences from SEQ ID NO:1-8, or in a sequence that is in strong linkage disequilibrium with a sequence of any of SEQ ID NO: 1-8, where the presence in position 27 C in SEQ ID NO:1, C in SEQ ID NO:2, T in SEQ ID NO:3, C in SEQ ID NO:4, C in SEQ ID NO:5, A in SEQ ID N0:6, T in SEQ ID NO:7 and G in SEQ ID NO:8, which corresponds to the access number in db SNP rs17465637, rs6725887, rs9818870, rs12526453, rs1333049, rs501120, rs9982601, rs10455872, respectively, or the presence of polymorphism in the sequence of any other rs, which is in strong linkage disequilibrium with any of said rs, is an indicator of the risk of having a cardiovascular event. Invention also relates to kits for implementing said method.;EFFECT: risk of developing cardiovascular events is assessed.;21 cl, 2 dwg, 8 tbl, 1 ex