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Universal field matching in craniospinal irradiation by a background‐dose gradient‐optimized method

机译:通过背景剂量梯度优化方法对颅骨脊髓照射进行通用场匹配

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Abstract PurposeThe gradient-optimized methods are overcoming the traditional feathering methods to plan field junctions in craniospinal irradiation. In this note, a new gradient-optimized technique, based on the use of a background dose, is described. MethodsTreatment planning was performed by RayStation (RaySearch Laboratories, Stockholm, Sweden) on the CT scans of a pediatric patient. Both proton (by pencil beam scanning) and photon (by volumetric modulated arc therapy) treatments were planned with three isocenters. An ‘in silico’ ideal background dose was created first to cover the upper-spinal target and to produce a perfect dose gradient along the upper and lower junction regions. Using it as background, the cranial and the lower-spinal beams were planned by inverse optimization to obtain dose coverage of their relevant targets and of the junction volumes. Finally, the upper-spinal beam was inversely planned after removal of the background dose and with the previously optimized beams switched on. ResultsIn both proton and photon plans, the optimized cranial and the lower-spinal beams produced a perfect linear gradient in the junction regions, complementary to that produced by the optimized upper-spinal beam. The final dose distributions showed a homogeneous coverage of the targets. DiscussionOur simple technique allowed to obtain high-quality gradients in the junction region. Such technique universally works for photons as well as protons and could be applicable to the TPSs that allow to manage a background dose.
机译:摘要目的梯度优化方法克服了传统的羽化方法来计划颅骨脊髓照射中的野结。在本说明中,描述了一种新的基于背景剂量的梯度优化技术。方法:由RayStation(RaySearch Laboratories,斯德哥尔摩,瑞典)对儿童患者的CT扫描进行治疗计划。计划使用三个等中心点进行质子(通过笔形束扫描)和光子(通过体积调制电弧疗法)治疗。首先创建了一个“计算机模拟”的理想背景剂量,以覆盖上脊髓靶标并沿上下连接区域产生理想的剂量梯度。将其作为背景,通过逆向优化计划颅骨和下椎骨梁,以获得其相关靶标和交界处的剂量覆盖率。最终,在去除背景剂量之后并打开先前优化的光束后,反向规划了上脊髓光束。结果在质子计划和光子计划中,优化的颅骨光束和下部脊柱光束在连接区域均产生完美的线性梯度,与优化的上部脊柱光束产生的线性梯度互补。最终剂量分布显示出靶标的均匀覆盖。讨论我们的简单技术允许在结区域获得高质量的梯度。这种技术普遍适用于光子以及质子,并且可以应用于允许管理背景剂量的TPS。

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